Major exclusion criteria included hypersensitivity to celecoxib, aspirin, other nonsteroidal anti inflammatory drugs NSAIDs, or sulfonamides; significant comorbidities including any active coronary artery disease requiring management, symptomatic congestive heart failure, bleeding diathesis, uncontrolled severe hypertension, active gastrointestinal ulcer within 12 months, chronic inflammatory bowel diseases, deep venous or arterial thrombosis within 12 months, history of pulmonary embolism; concomitant use of possible interactive drugs including chronic use of other NSAIDs; surgery, chemotherapy or radiotherapy within 1 month; actual or potential childbearing; breast feeding; prior cancer treatment with a COX 2 inhibitor; any psychological, sociological or geographical condition potentially hampering compliance with the study protocol and follow up schedule <a href=http://accutane.one>accutane for rosacea</a> Miller TW, Rexer BN, Garrett JT, et al